Prophylactic and Therapeutic Methods Against Histomoniasis in Poultry

Nguyen Van Phuong 1 and Bui Khanh Linh 1

1Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 131000, Vietnam
Received: May 14, 2020 /
Revised: Jul 12, 2021 /
Published: Nov 30, 2020

Main Article Content

Full-Text | pdf

Abstract

Histomoniasis, commonly known as blackhead disease, is a parasitic disease in poultry caused by the protozoan Histomonas meleagridis. The availability of various compounds for chemotherapy in the 1970s resulted in the successful control of blackhead disease. Since the ban of antihistomonal drugs in the European Union, the disease has re-emerged, resulting in up to 100% mortality in turkey flocks. This has renewed the interest of scientists with numerous publications focusing on prophylactic strategies. This review summarizes the literature on the preventive and curative options for the control and treatment of histomoniasis. Two main approaches to the prophylaxis of the disease were found, which included chemotherapies and plant substrate products. Histostat-50 and paromomycin were the only available drugs that showed antihistomonal activity despite some concern about their threat to human health and antibiotic resistance. None of the plant substrate products provided potential protection to birds against blackhead disease. The use of attenuated histomonads could be an alternative for the prevention of the disease, but the production of this vaccine prototype is still challenging due to advanced technique requirements.

Keywords: Histomoniasis, Histomonas meleagridis, parasitic in poultry, prophylactic, therapeutic

Article Details

How to Cite
Phuong, N., & Linh, B. (2020). Prophylactic and Therapeutic Methods Against Histomoniasis in Poultry. Vietnam Journal of Agricultural Sciences, 3(2), 593-605. https://doi.org/10.31817/vjas.2020.3.2.03

References

    Abraham M., McDougald L. R. & Beckstead R. B. (2014). Blackhead disease: Reduced sensitivity of Histomonas meleagridis to nitarsone in Vitro and in Vivo. Avian diseases. 58(1): 60-63.
    Administration USFaD. FDA. (2015). Announces Pending Withdrawal of Approval of Nitarsone. Retrieved from https://www.ngfa.org/news/feed-news/fda-announces-pending-withdrawal-of-nitarsone-for-use-in-turkeys-chicken/#:~:text=The%20Food%20and%20Drug%20Administration,by%20the%20end%20of%202015. on October 10, 2019.
    Araújo J. L., Olinda R. G., Frade M. T. S., Maia L. Â. & Dantas A. F. M. (2015). Histomoniasis outbreak in free-range chickens in semiarid Paraíba, Brazil. Semina: Ciências Agrárias. 36(1): 307-312.
    Bleyen N., De Gussem K., Nguyen Pham Anh Dao, Ons E., Van Gerven N. & Goddeeris B. M. (2009). Non-curative, but prophylactic effects of paromomycin in Histomonas meleagridis-infected turkeys and its effect on performance in non-infected turkeys. Veterinary Parasitology. 165(3-4): 248-255.
    Bleyen N., Ons E., De Gussem M. & Goddeeris B. M. (2009). Passive immunization against Histomonas meleagridis does not protect turkeys from an experimental infection. Avian Pathology. 38(1): 71-76.
    Byrne D. (2001). Commission Regulation (EC) No. 2205/2001 of November 14, 2001 amending Council Directive 70/524/EEC concerning additives in feedingstuffs as regards withdrawal of the authorisation of certain additives 2001. Retrieved from https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32001R2205 on October 10, 2019.
    Cushman S. (1893). The production of turkeys. Rhode Island Agricultural Experiment Station Bulletin. 25: 89-123.
    Duffy C. F., Sims M. D. & Power R. F. (2005). Evaluation of dietary Natustat for control of Histomonas meleagridis in male turkeys on infected litter. Avian Diseases. 49(3):423-425.
    Duffy C. F., Sims M. D. & Power R. F. (2004). Preliminary evaluation of dietary natustat™ versus histostat® (Nitarsone) for control of Histomonas meleagridis in broiler chickens on infected litter. International Journal of Poultry Science. 3(12): 753-757.
    EFSA (2009). Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) on a request from the European Commission on the preliminary evaluation of the safety and efficacy of paromomycin sulphate for turkeys for fattening and turkeys reared for breeding. The EFSA Journal. 1095: 1-22.
    Esquenet C., De Herdt P., De Bosschere H., Ronsmans S., Ducatelle R. & Van Erum J. (2003). An outbreak of histomoniasis in free-range layer hens. Avian Pathology. 32(3): 305-308.
    Grabensteiner E., Liebhart D., Arshad N. & Hess M. (2008) Antiprotozoal activities determined in vitro and in vivo of certain plant extracts against Histomonas meleagridis, Tetratrichomonas gallinarum and Blastocystis sp. Parasitology research. 103(6): 1257-1264.
    Grabensteiner E., Liebhart D., Weissenböck H. & Hess M. (2006). Broad dissemination of Histomonas meleagridis determined by the detection of nucleic acid in different organs after experimental infection of turkeys and specified pathogen-free chickens using a mono-eukaryotic culture of the parasite. Parasitology International. 55(4): 317-322.
    Hafez H. M., Schulze D., Hauck R. & Lüschow D. (2005). Histomonas meleagridis: The Situation after the Ban of the Last Available Drug in the EU. Proceedings of the fifty-fourth Western pounltry disease conference. Vancouver, B.C., Canada.
    Hafez H.M., Hauck R., Gad W., De Gussem K. & Lotfi A. (2010). Pilot study on the efficacy of paromomycin as a histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis. Archives of Animal Nutrition. 64(1): 77-84.
    Hafez H. M. & Hauck R. (2006). Efficacy of a herbal product against Histomonas meleagridis after experimental infection of turkey poults. Archives of Animal Nutrition. 60(5): 436-642.
    Hauck R., Armstrong P. L., Fuller L. & McDougald L. R. (2007). The effect of Natustat® on Histomoniasis in turkeys. Proceedings of the 56th Western poultry disease . March 26-29, 2007. Las Vegas, Nevada. 102-104.
    Hauck R., Balczulat S. & Hafez H. M. (2010). Detection of DNA of Histomonas meleagridis and Tetratrichomonas gallinarum in German poultry flocks between 2004 and 2008. Avian Diseases. 54(3): 1021-1025.
    Hess M., Liebhart D., Grabensteiner E. & Singh A. (2008). Cloned Histomonas meleagridis passaged in vitro resulted in reduced pathogenicity and is capable of protecting turkeys from histomonosis. Vaccine. 26(33): 4187-4193.
    Hu J. & McDougald L. R. (2004). The efficacy of some drugs with known antiprotozoal activity against Histomonas meleagridis in chickens. Veterinary parasitology. 121(3-4): 233-238.
    Kawalek J. C., Carson M., Conklin S., Lancaster V., Howard K. & Ward J. (2011). Provide data on various arsenic species present in broilers treated with roxarsone: comparison with untreated birds. Final report on Study 275.30. 2011. US Food and Drug Administration: Laurel, MD, USA.
    Kempf I., Le Roux A., Perrin-Guyomard A., Mourand G., Le Devendec L., Bougeard S., Richez P., Le Pottier G. & Eterradossi N. (2013). Effect of in-feed paromomycin supplementation on antimicrobial resistance of enteric bacteria in turkeys. The Veterinary Journal. 198(2): 398-403. DOI: 10.1016/j.tvjl.2013.05.030.
    Liebhart D., Windisch M. & Hess M. (2010). Oral vaccination of 1-day-old turkeys with in vitro attenuated Histomonas meleagridis protects against histomonosis and has no negative effect on performance. Avian Pathology. 39(5): 399-403.
    Lund E. E. & Burtner Jr R. H. (1957). Infectivity of Heterakis gallinae eggs with Histomonas meleagridis. Experimental Parasitology. 6(2):189-93. DOI: 10.1016/0014-4894(57)90014-0.
    McDougald L. R. & Fuller L. (2005). Blackhead disease in turkeys: direct transmission of Histomonas meleagridis from bird to bird in a laboratory model. Avian Diseases. 49(3): 328-331.
    McDougald L. R. & Hu J. (2001). Blackhead disease (Histomonas meleagridis) aggravated in broiler chickens by concurrent infection with cecal coccidiosis (Eimeria tenella). Avian Diseases. 45(2): 307-312.
    Nguyen Duc Tan, Bilic I., Jaskulsa B., Hess M. B., Le Duc Quyet, Le Hua Ngoc Luc, Huynh Vy Vu, Nguyen Thi Sam & Vu Khac Hung (2015). Prevalence and genetic characterization of Histomonas meleagridis in chickens in Vietnam. Avian diseases. 59(2):309-314. DOI: 10.1637/10964-102414-Reg.
    Nguyen Pham Anh Dao., De Gussem J. K. & Goddeeris B. M. (2013). Intracloacally passaged low-virulent Histomonas meleagridis protects turkeys from histomonosis. Veterinary Parasitology. 196(3): 307-313.
    Reece R. L., Beddome V. D. & Barr D. A. (1986). Diseases diagnosed in replacement layer and breeder chicken flocks in Victoria, Australia, 1977 to 1985. Veterinary
    Record. 119(19): 471-475.
    Somkid K. P. K. & Niwat C. (2006). Outbreak of histomoniasis in cross breed native chickens from one private farm in Nakorn Pathom province. Retrieved from http://agris.fao.org/agris-search/search.do?recordID=TH2006000328 on October 18, 2019.
    Swayne DEG. J. R., McDougald L. R., Nolan L. K., Suarez D. L. & Nair V. (2013). Diseases of Poultry. 13, editor: John Wiley & Sons, Inc; 1423.
    van der Heijden H. M. J. F., De Gussem K. & Landman W. J. M. (2011). Assessment of the antihistomonal effect of paromomycin and tiamulin. Tijdschrift Voor Diergeneeskunde. 136(6): 410-416.
    van der Heijden H. M. (2009). Detection, typing and control of Histomonas meleagridis. Retrieved from http://dspace.library.uu.nl/bitstream/handle/1874/32242/heijden.pdf?sequence=1 on October 18, 2019.
    van der Heijden H. M. J. F. & Landman W. J. M. (2008a). In vitro effect of herbal products against Histomonas meleagridis. Veterinary Parasitology. 154(1): 1-7.
    van der Heijden H. M. & Landman W. J. M. (2008b). In vivo effect of herbal products against Histomonas meleagridis in turkeys. Avian Pathology: journal of the WVPA. 37(1): 45-50.
    Waters S. M., Duffy C. F. & Power R. F. G. (2005). PCR-DGGE analysis of caecal microflora of Natustat™ supplemented turkeys challenged with Histomonas meleagridis. International Journal of Poultry Science. 4(9): 620-627.
    Zahoor M. A., Liebhart D. & Hess M. (2011). Progression of histomonosis in commercial chickens following experimental infection with an in vitro propagated clonal culture of Histomonas meleagridis. Avian Diseases. 55(1): 29-34. DOI: 10.1637/9508-082110-Reg.1.
    Zenner L., Callait M. P., Granier C. & Chauve C. (2003). In vitro effect of essential oils from Cinnamomum aromaticum, Citrus limon and Allium sativum on two intestinal flagellates of poultry, Tetratrichomonas gallinarum and Histomonas meleagridis. Parasite. 10(2): 153-157. DOI: 10.1051/parasite/2003102153.