The Use of Drugs, Chemicals, Herbs, and Herbal Extract Products in Grow-out Farms of Snakehead (Channa striata) and Pangasius Catfish (Pangasianodon hypophthalmus) in the Mekong Delta, Vietnam

Nguyen Le Anh Dao 1 , Nguyen Quoc Thinh 1 , Vo Nam Son 1 , Huynh Van Hien 1 , Nguyen Thanh Phuong 1 , Do Thi Thanh Huong 1 , Bui Thi Bich Hang 1 , Marie-Louise Scippo 2 , Joëlle Quetin-Leclercq 3 , Patrick Kestemont 4 and Tran Minh Phu 1

1College of Aquaculture and Fisheries, Can Tho University, Can Tho 9400, Vietnam
2Laboratory of Food Analysis, University of Liège, Liege 4000, Belgium
3Louvain Drug Research Institute, Pharmacognosy Research Group, Université Catholique De Louvain, Brussels 1048, Belgium
4Research Unit in Environmental and Evolutionary Biology, Research Institute of Life, Earth & Environment (ILEE), University of Namur, Namur 5001, Belgium
Received: Nov 13, 2020 /
Revised: Mar 30, 2022 /
Published: Mar 30, 2022

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This study aimed to investigate the current use of drugs, chemicals, herbs, and herbal extract products in grow-out farms of snakehead (Channa striata) and Pangasius catfish (Pangasianodon hypophthalmus) in the Mekong Delta, Vietnam. The survey was conducted with a total of 60 Pangasius catfish grow-out farms in An Giang and Dong Thap provinces, and 60 snakehead grow-out farms in An Giang and Tra Vinh provinces. The results showed that bacterial diseases were commonly reported by snakehead farmers (1-4 episodes per crop) and Pangasius catfish farmers (1 to 12 episodes per crop). Farmers used 12 types of single antibiotics and a mixture of two antibiotics in Pangasius catfish, and eight types of antibiotics in snakehead aquaculture. However, Pangasius catfish and snakehead farmers used enrofloxacin and ciprofloxacin, which are banned antibiotics according to the Vietnamese authority regulations. For the use of herbs and herbal extract products, a variety of commercial products were used by farmers which claimed different purposes for use. According to the farmers, the quality and effectiveness of these products were questionable. Some farmers used traditional herbs following their experiences using traditional medicines for humans and did not really know about the application doses. Thus, it would be requested for in-depth studies on the use of herbs as on-farm treatments, which would provide evidence for the use of herbs in the industry.

Keywords: Antimicrobial, herbal, Mekong delta, snakehead, Pangasius catfish

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How to Cite
Dao, N., Thinh, N., Son, V., Hien, H., Phuong, N. T., Thi Thanh Huong, D., Thi Bich Hang, B., Scippo, M.-L., Quetin-Leclercq, J., Kestemont, P., & Phu, T. (2022). The Use of Drugs, Chemicals, Herbs, and Herbal Extract Products in Grow-out Farms of Snakehead (Channa striata) and Pangasius Catfish (Pangasianodon hypophthalmus) in the Mekong Delta, Vietnam. Vietnam Journal of Agricultural Sciences, 5(1), 1336-1344.


    Blumenthal M., Goldberg A., & Brinckmann J. (2000). Herbal medicine: Expanded commission E monographs: Integrative Medicine Communications.
    Bussmann R. W., Malca-García G., Glenn A., Sharon D., Chait G., Díaz D., Pourmand K., Jonat B., Somogy S., & Guardado G. (2010). Minimum inhibitory concentrations of medicinal plants used in Northern Peru as antibacterial remedies. Journal of Ethnopharmacology. 132(1): 101-108. DOI: 10.1016/j.jep.2010.07.048.
    Chakraborty S. B. & Hancz C. (2011). Application of phytochemicals as immunostimulant, antipathogenic and antistress agents in finfish culture. Reviews in Aquaculture. 3(3): 103-119.
    Citarasu T. (2010). Herbal biomedicines: a new opportunity for aquaculture industry. Aquaculture International. 18(3): 403-414. DOI: 10.1111/j.1753-5131.2011.01048.x.
    Dang Thuy Mai Thy, Bui Thi Bich Hang & Tran Thi Tuyet Hoa (2020). Antifungal activity of extracted herbs on snakehead pathogenic fungal. Can Tho University Journal of Science. 56(1): 129-136. DOI: 10.22144/ctu.jsi.2020.015 (in Vietnamese).
    De Silva S. S., & Phuong N. T. (2011). Striped catfish farming in the Mekong Delta, Vietnam: a tumultuous path to a global success. Reviews in Aquaculture, . 3(2): 45-73. DOI: 10.1111/j.1753-5131.2011.01046.x.
    Directorate of Fisheries (2020). Reduction of striped catfish export in 2019. Retrieved on September 22, 2020 from on September 22, 2020.
    Fawole F. J., Sahu N. P., Pal A. K., & Ravindran A. (2016). Haemato‐immunological response of Labeo rohita (Hamilton) fingerlings fed leaf extracts and challenged by Aeromonas hydrophila. Aquaculture Research., 47(12): 3788-3799. DOI: 10.1111/are.12829.
    Ghehdarijani M. S., Hajimoradloo A., Ghorbani R., & Roohi Z. (2016). The effects of garlic-supplemented diets on skin mucosal immune responses, stress resistance and growth performance of the Caspian roach (Rutilus rutilus) fry. Fish and Shellfish Immunology., 49: 79-83. DOI: 10.1016/j.fsi.2015.12.021.
    Giri S. S., Sen S. S., Chi C., Kim H. J., Yun S., Park S. C. & Sukumaran V. (2015). Effect of guava leaves on the growth performance and cytokine gene expression of Labeo rohita and its susceptibility to Aeromonas hydrophila infection. Fish and Shellfish Immunology. 46(2): 217-224. DOI: 10.1016/j.fsi.2015.05.051.
    Gobi N., Ramya C., Vaseeharan B., Malaikozhundan B., Vijayakumar S., Murugan K. & Benelli G. (2016). Oreochromis mossambicus diet supplementation with Psidium guajava leaf extracts enhance growth, immune, antioxidant response and resistance to Aeromonas hydrophila. Fish and Shellfish Immunology. 58: 572-583. DOI: 10.1016/j.fsi.2016.09.062.
    Hoseinifar S. H., Khalili M., Rufchaei R., Raeisi M., Attar M., Cordero H., & Esteban M. Á. (2015). Effects of date palm fruit extracts on skin mucosal immunity, immune related genes expression and growth performance of common carp (Cyprinus carpio) fry. Fish and Shellfish Immunology. 47(2): 706-711. DOI: 10.1016/j.fsi.2015.09.046.
    Huynh Van Hien, Nguyen Hoang Huy & Nguyen Thi Minh Thuy (2011). Technical and economical comparison of snakehead (Channa striata) pond culture by trashfish and commercial pelled feed in An Giang and Dong Thap provinces, Vietnam. Proceedings of Vietnam National Aquaculture Conference. Nong Lam University: 480-487.
    Kim Van Van (2012). The use of garlic in treatment of bacterial disease. In: Phu T. Q. (Eds.). Principals and technique in aquaculture. Agriculture Publisher, HCMC. 170 pages.
    Logambal S., Venkatalakshmi S. & Michael R. D. (2000). Immunostimulatory effect of leaf extract of Ocimum sanctum Linn. in Oreochromis mossambicus (Peters). Hydrobiologia, 430(1-3): 113-120. DOI: 10.1023/A:1004029332114.
    Mai Van Tai (2012). Use of veterinary medicines in Vietnamese aquaculture: current status. FAO Fisheries and Aquaculture Technical Paper. (547): 91-98.
    MARD (2016). Circular No. 10/2016/TTBNN dated July 16th, 2016 on the list of drugs, chemicals and antibiotics banned or restricted to use in Vietnamese aquaculture. Retrieved on November 30, 2019 from on November 30, 2019 (in Vietnamese).
    Dao N. L. A., Phu T. M., Douny C., Quetin-Leclercq J., Hue B. T. B, Bach L. T., Nhu T. Q., Hang B. T. B., Huong D. T. T., Phuong N. T., Kestemont P. & Scippo M.-L. (2020). Screening and comparative study of in vitro antioxidant and antimicrobial activities of ethanolic extracts of selected Vietnamese plants. International Journal of Food Properties., 23(1): 481-496. DOI: 10.1080/10942912.2020.1737541.
    Nguyen Phu Hoa (2012). The use of Yucca extract in aquaculture. In: Truong Quoc Phu (Ed.). Principals and technique in aquaculture. Agriculture Publisher, HCMC: 170 pages (in Vietnamese).
    Nguyen Quoc Thinh, Masashi Maita & Tran Minh Phu (2020). Status of diseases, drugs and chemicals use in snakehead (Channa striata) culture in An Giang and Tra Vinh provinces. Can Tho University Journal of Science. Specialized in Aquaculture. 56(2): 179-184 (in Vietnamese). DOI: 10.22144/ctu.jsi.2020.020.
    Nguyen Quoc Thinh, Tran Minh Phu, Huynh So Ni, Sebastien Quennery, Do Thi Thanh Huong, Nguyen Thanh Phuong, Patrick Kestemont & Marie Louise Scippo (2014). Situation of chemicals used in rice‐fish, stripped catfish cultured in pond and red tilapia cultured in cage in Mekong Delta Can Tho University Journal of Science. 2: 278-283 (in Vietnamese).
    Nhu T. Q., Dam N. P., Hang B. T. B., Hue B. T. B., Scippo M.-L., Phuong N. T., Quetin-Leclercq J., & Kestemont P. (2020). Immunomodulatory potential of extracts, fractions and pure compounds from Phyllanthus amarus and Psidium guajava on striped catfish (Pangasianodon hypophthalmus) head kidney leukocytes. Fish and Shellfish Immunology. DOI: 10.1016/j.fsi.2020.05.051.
    Nhu T. Q., Hang B. T. B., Hue B. T. B., Quetin-Leclercq J., Scippo M.-L., Phuong N. T., & Kestemont P. (2019). Plant extract-based diets differently modulate immune responses and resistance to bacterial infection in striped catfish (Pangasianodon hypophthalmus). Fish and Shellfish Immunology. 92: 913-924. DOI: 10.1016/j.fsi.2019.07.025.
    Nhu T. Q., Hang B. T. B., Vinikas A., Hue B. T. B., Quetin-Leclercq J., Scippo M.-L., Phuong N. T., & Kestemont P. (2019). Screening of immuno-modulatory potential of different herbal plant extracts using striped catfish (Pangasianodon hypophthalmus) leukocyte-based in vitro tests. Fish and Shellfish Immunology. 93: 296-307. DOI: 10.1016/j.fsi.2019.07.064.
    Ocheng F., Bwanga F., Joloba M., Borg-Karlson A.-K., Gustafsson A. & Obua C. (2014). Antibacterial activities of extracts from Ugandan medicinal plants used for oral care. Journal of ethnopharmacology., 155(1): 852-855. DOI: 10.1016/j.jep.2014.06.027.
    Pham Minh Duc, Tran Thi Thanh Hien & Tran Ngoc Tuan (2012). An investigation on pathogen infection to cultured snakehead (Channa striata) in An Giang and Dong Thap provinces. Can Tho University Journal of Science. 21b: 124-132 (in Vietnamese).
    Phan L. T., Bui T. M., Nguyen T. T., Gooley G. J., Ingram B. A., Nguyen H. V., Nguyen P. T. & De Silva S. S. (2009). Current status of farming practices of striped catfish, Pangasianodon hypophthalmus in the Mekong Delta, Vietnam. Aquaculture. 296(3-4): 227-236. DOI: 10.1016/j.aquaculture.2009.08.017.
    Phu T. M., Phuong N. T., Dung T. T., Hai D. M., Son V. N., Rico A., Clausen J. H., Madsen H., Murray F., & Dalsgaard A. (2016). An evaluation of fish health‐management practices and occupational health hazards associated with Pangasius catfish (Pangasianodon hypophthalmus) aquaculture in the Mekong Delta, Vietnam. Aquaculture Research. 47(9): 2778-2794. DOI: 10.1111/are.12728.
    Ström G. H., Björklund H., Barnes A. C., Da C. T., Nhi N. H. Y., Lan T. T., Magnussion U., Haldén A. N., & Boqvist, S. (2019). Antibiotic Use by Small‐Scale Farmers for Freshwater Aquaculture in the Upper Mekong Delta, Vietnam. Journal of Aquatic Animal Health. 31(3): 290-298. DOI: 10.1002/aah.10084.
    Sukumaran V., Park S. C. & Giri S. S. (2016). Role of dietary ginger Zingiber officinale in improving growth performances and immune functions of Labeo rohita fingerlings. Fish and Shellfish Immunology., 57: 362-370. DOI: 10.1016/j.fsi.2016.08.056.
    Tekwu E. M., Pieme A. C. & Beng V. P. (2012). Investigations of antimicrobial activity of some Cameroonian medicinal plant extracts against bacteria and yeast with gastrointestinal relevance. Journal of Ethnopharmacology. 142(1): 265-273. DOI: 10.1016/j.jep.2012.05.005.
    Tran Hoang Tuan, Tran Ngoc Hai, Truong Hoang Minh, Huynh Van Hien, Robert S. Pomeroy & Nguyen Tuan Loc (2014). Assessment on production efficiency and weather change impacts on snakehead pond culture in An Giang and Tra Vinh provinces. Can Tho University Journal of Science. Specialized in Aquaculture: 141-149 (in Vietnamese).
    Tran Minh Phu, Nguyen Tam Em, Nguyen Quoc Thinh, Phung Thi Truc Ha, Nguyen Khanh Nam, Do Thi Thanh Huong & Nguyen Thanh Phuong (2017). The use of drug, chemical, and probiotic in red tilapia (Oreochromis sp.) cage culture in Mekong Delta, Vietnam. Can Tho University Journal of Science. 51b: 80-87 (in Vietnamese).