Phytochemical Analysis and Antioxidant and Alpha-glucosidase Inhibitory Activities of the Stem Bark of Dialium cochinchinense Pierre

Date Received: Jun 18, 2020

Date Published: Mar 30, 2022

DOI: https://doi.org/10.31817/vjas.2022.5.1.06

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Issue: Vol. 5 No. 1 (2022): Vietnam Journal of Agricultural Sciences

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NATURAL RESOURCES AND ENVIRONMENT

How to Cite:

Trang, T., Ha, L., Ai, D., Hien, N., Tram, N., & Huyen, V. (2022). Phytochemical Analysis and Antioxidant and Alpha-glucosidase Inhibitory Activities of the Stem Bark of Dialium cochinchinense Pierre. Vietnam Journal of Agricultural Sciences, 5(1), 1375–1388. https://doi.org/10.31817/vjas.2022.5.1.06

Phytochemical Analysis and Antioxidant and Alpha-glucosidase Inhibitory Activities of the Stem Bark of Dialium cochinchinense Pierre

Tran Thi Thu Trang 1 , Lai Thi Ngoc Ha 1 , Doan Thi Thuy Ai 2 , Nguyen Thi Hien 2 , Nguyen Thi Thu Tram 3   , Vu Thi Huyen (*) 2

  • Corresponding author: vthuyen@vnua.edu.vn
  • 1 Faculty of Food Science and Technology, Vietnam National University of Agriculture, Hanoi 131000, Vietnam
  • 2 Faculty of Environment, Vietnam National University of Agriculture, Hanoi 131000, Vietnam
  • 3 Faculty of Sciences, Can Tho University of Medicine and Pharmacy, Hanoi 94100, Vietnam

    • Keywords

    Antioxidant, Caesalpinioideae, Dialium cochinchinense, Phytochemical, α-glucosidase

    Abstract


    The purpose of this study was to determine the phytochemical compositions and to evaluate the biological activity of the stem bark of Dialium cochinchinense. The phytochemical analysis showed the presence of steroids, terpenoids, anthraquinones, saponins, and phenolics in the stem bark of D. cochinchinense. The optimal extraction conditions were 70% ethanol at 30°C for 40min with a material/solvent ratio of 1/20. Under the optimal conditions, the corresponding predicted response value for the total phenolic content was 100.80 ± 0.40 mg GAE/g DW. The evaluation of antioxidant activity indicated that the polyphenol-rich extract was a good source of antioxidants as measured by the DPPH assay with the IC50 of 3.81 ± 0.58 μg mL-1. The extract also demonstrated a strong a-glucosidase inhibitory activity with the IC50 value of 2.14 ± 0.05 μg/mL. Therefore, D. cochinchinense could be useful as a potential preventive intervention for free radicals in mediated diseases as well as an antioxidant drug and a potential source in treating diabetes mellitus in the pharmaceutical industry.

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