An Overview of Drug Effects on Bone Healing on Animal Research Models

Date Received: May 19, 2019

Date Published: Jun 18, 2021

DOI: https://doi.org/10.31817/vjas.2021.4.1.08

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Nam, N., & Kampa, N. (2021). An Overview of Drug Effects on Bone Healing on Animal Research Models. Vietnam Journal of Agricultural Sciences, 4(1), 978–988. https://doi.org/10.31817/vjas.2021.4.1.08

An Overview of Drug Effects on Bone Healing on Animal Research Models

Nguyen Hoai Nam (*) 1   , Kampa Naruepon 2

  • Corresponding author: nguyenhoainam@vnua.edu.vn
  • 1 Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 131000, Vietnam
  • 2 Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

    • Keywords

    Animal model, bone healing, drug, rat femur

    Abstract


    Bone fracture is a common health problem in humans and animals, and the healing of the bone fracture is a complicated process. Several drugs may be used concurrently with the treatment of fractures, but they may interfere with the healing process of the bone. The present research reviewed previously published studies with the objective to enhance the understandings of the effects of different drugs on bone healing. There is clear evidence that antibiotics, corticosteroids, non-steroidal inflammatory drugs, and chemotherapeutic drugs all affect bone healing. By contrast, the effect of anticoagulants on bone healing is controversial, so more research is needed to determine its efficacy. In addition, there is no direct evidence to approve the effect of anesthetics on bone healing, so this is another area in need of further research.

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