Date Received: Dec 24, 2018
Date Published: Jun 07, 2019
Views
Download
Section:
How to Cite:
Additive Genetic Effects of RNF4, RBP4, and IGF2 Polymorphisms on Litter Size in Landrace and Yorkshire Sows
,
Do Duc Luc
2, 3
,
Nguyen Hoang Thinh
1
,
Ha Xuan Bo
1
,
Hoang Ngoc Mai
4
,
Nguyen Thi Phuong
4
,
Frederic Farnir
5
,
Vu Dinh Ton
1
Keywords
RNF4, RBP4, IGF2, additive genetic effect, litter size
Abstract
The association of the RNF4, RBP4, and IGF2 genotypes and their additive genetic effects with litter size in purebred Landrace and Yorkshire sows were studied. The results revealed significant associations between the RNF4 and RBP4 genotypes with the total number of piglets born (TNB) and number of piglets born alive (NBA) traits (P <0.05). The RNF4 CC genotype had greater TNB and NBA than the TT genotype in both breeds. The RBP4 BB genotype had greater TNB and NBA than the AA genotype in the Landrace breed. Significant additive effects of the RNF4 and RBP4 genes on the TNB and NBA were detected (P <0.05). No significant associations of the IGF2 genotypes and their additive effects with any reproductive traits were observed in both Landrace and Yorkshire sows (P >0.05). The results suggested that the RNF4 and RBP4 genes could be useful in selection for increasing TNB and NBA traits in pigs.
References
Blowe C. D., Boyette K. E., Ashwell M. S., Eisen E. J., Robinson O. W. & Cassady J. P. (2006). Characterization of a line of pigs previously selected for increased litter size for RBP4 and follistatin. Journal of Animal Breeding and Genetics. 123: 389-395.
Curtin D., Ferris H. A., Hakli M., Gibson M., Janne O. A., Palvimo J. J. & Shupnik M. A. (2004). Small nuclear RING finger protein stimulates the rat luteinizing hormone-beta promoter by interacting with Sp1 and steroidogenic factor-1 and protects from androgen suppression. Molecular Endocrinology. 18: 1263-1276.
Distl O. (2007). Mechanisms of regulation of litter size in pigs on thegenome level. Reproduction in Domestic Animals. 42: 10-16.
Drogemuller C., Hamann H. & Distl O. (2001). Candidate gene markers for litter size in different German pig lines. Journal of Animal Science. 79(10): 2565-2570.
Horák P., Miková G., Urban T., Putnová L., Knoll A. & Dvorák K. J. (2001). Association of polymorphism in the IGF2 gene with litter size in Black Pied Prestice pigs. Czech Journal of Animal Science. 46: 505-508.
Jeon J. T., Carlborg O. & Törnsten A. (1999). A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus. Nature Genetics. 21: 157-165.
Knoll A., Putnová L., Dvorák K. J. & Cepica S. (2000). A NciI PCR-RFLP within intron 2 of the porcine insulin-like growth factor 2 (IGF2) gene. Animal Genetics. 31: 150-151.
Linville R. C., Pomp D., Johnson R. K. & Rothschild M. F. (2001). Candidate gene analysis for loci affecting litter size and ovulation rate in swine. Journal of Animal Science. 79: 60-67.
Marantidis A., Laliotis G. P. & Avdi M. (2015). Association of RBP4 genotype with phenotypic reproductive traits of sows. Genetic Research International. 2016: 1-5.
Messer L., Wang L., Yelich J., Pomp D., Geisert R. & Rothschild M. F. (1996). Linkage mapping of the retinol-binding protein (RBP4) gene to porcine chromosome 14. Mammalian Genome. 7: 396.
Moilanen A. M., Poukka H., Karvonen U., Hakli M., Janne O. A. & Palvimo J. J. (1998). Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Molecular Cell Biology. 18(9): 5128-5139.
Nezer C., Moreau L., Brouwers B., Coppieters W., Detilleux J., Hanset R., Karim L., Kvasz A., Leroy P. & Georges M. (1999). An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus. Nature Genetics. 21: 155-156.
Niu B. Y., Ye L. Z., Li F. E., Deng C. Y., Jiang S. W., Lei M. G. & Xiong Y. Z. (2009). Identification of polymorphism and association analysis with reproductive traits in the porcine RNF4 gene. Animal Reproduction Science. 110(3-4): 283-292.
Omelka R., Martiniaková M., Peškovičová D. & Bauerová M. (2008). Associations between RBP4/MspI polymorphism and reproductive traits in pigs: an application of animal model. Journal of Agrobiology. 25: 77-80.
Rothschild F. M., Messer L., Day L., Wales R., Short T., Southwood O. & Plastow G. (2000). Investigation of the retinol-binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs. Mammalian Genome. 11(1): 75-77.
Saville B., Poukka H., Wormke M., Janne O. A., Palvimo J. J., Stoner M., Samudio I. & Safe S. (2002). Cooperative coactivation of estrogen receptor α in ZR-75 human breast cancer cells by SNURF and TATA-binding protein. Journal of Biological Chemistry. 277: 2485-2497.
Spotter A., Muller S., Hamann H. & Distl O. (2009). Effect of polymorphisms in the genes for LIF and RBP4 on litter size in two German pig lines. Reproduction in Domestic Animals. 44(1): 100-105.
Spotter A. & Distl O. (2006). Genetic approaches to the improvement of fertility traits in the pig. Veterinary Journal. 172(2): 234-247.
Terman A., Kmieć M., Polasik D. & Pradziadowicz K. (2007). Retinol binding protein 4 gene and reproductive traits in pigs. Arch Tierzcht Dummerstorf. 50: 181-185.
Trout W. E., McDonnell J. J., Kramer K. K., Baumbach G. A. & Robert R. M. (1991). The retinol-binding protein of the expanding pig blastocyst: molecular cloning and expression in trophectoderm and embyronic disc. Molecular Endocrinology. 5: 1533-1540.
Wang X., Wang A., Fu J. & Lin H. (2006). Effects of ESR1, FSHB and RBP4 genes on litter size in a Large White and a Landrace herd. Arch Tierzcht Dummerstorf. 49: 64-70.
Yelich J. V., Pomp D. & Geisert R. D. (1997). Ontogeny of elongation and gene expression in the early developing porcine conceptus. Biology of Reproduction. 57: 1256-1265.