Association between the MUC4 g.243A>G Polymorphism and Production Performance of Landrace and Yorkshire Pigs in Vietnam

Do Duc Luc 1 , Nguyen Hoang Thinh 1 , Ha Xuan Bo 1 , Do Thi Phuong 2 , Phan Thi Tuoi 3 , Vu Dinh Ton 3 and Frederic Farnir 4

1Faculty of Animal Science, Vietnam National University of Agriculture, Hanoi 131000, Vietnam
2Asia Livestock Innovation Center, Sunjin Vina Co., Ltd, Ha Nam Branch, Ha Nam 400000, Vietnam
3Faculty of Agriculture – Forestry - Fishery, Hong Duc University, Thanh Hoa 441539, Vietnam
4Unit of Biostatistics, Bioinformatics, Economics, Animal Selection, University of Liège, Liège 4000, Belgium
Received: Apr 12, 2022 /
Revised: Mar 29, 2023 /
Published: Mar 29, 2023

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Porcine mucin 4 (MUC4) is a candidate gene for controlling the adhesion of the enterotoxigenic Escherichia coli (ETEC) F4 receptor. Polymorphisms of the MUC4 gene have been used as markers to identify the susceptibility of neonatal diarrhea in piglets for breeding selection. The objective of this study was to evaluate the effects of MUC4 g.243A>G polymorphisms on the production traits of Landrace and Yorkshire pigs in Vietnam. A total of 1,057 Landrace and 1,361 Yorkshire piglets were used to estimate the allelic and genotypic frequencies of the polymorphisms. Body weights at birth, at weaning, at initial fattening (IBW), and at the end of fattening period (FBW), backfat thickness (BFT), and depth of the longissimus dorsi muscle (DLD) were measured and lean meat percentage was estimated. Frequency of the susceptibility allele A to ETEC was higher than the resistance allele G for both breeds based on genotyping piglet tails collected at birth. The AA, AG, and GG genotypes were present in Yorkshire while GG was not found in Landrace. The production traits were not affected (P >0.05) by MUC4 polymorphisms except BFT and DLD (P <0.05). There were interactions between gender and MUC4 genotype (P <0.05) for IBW, FBW, average daily gain, and DLD. These traits of GG males were significantly higher than those of GG females (P <0.05). The results suggest that selecting pigs carrying the GG genotype of MUC4, known as providing resistance to ETEC, do not negatively affect productive performance in Landrace and Yorkshire pigs.

Keywords: Swine, growth, polymorphisms, diarrhea resistance

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How to Cite
Luc, D., Thinh, N., Bo, H., Phuong, D., Tuoi, P., Ton, V., & Farnir, F. (2023). Association between the MUC4 g.243A&gt;G Polymorphism and Production Performance of Landrace and Yorkshire Pigs in Vietnam. Vietnam Journal of Agricultural Sciences, 6(1), 1711-1718.


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